APPLICATIONS - AAV · LNP · tLNP
See more in every sample of nanoparticles
Multi-parameter characterization of complex nanoparticles for gene therapy and other advanced therapeutics.
Measurements - Size · Mass · Cargo
The need
Complex particles need a clearer picture.
AAV and lipid nanoparticles carry therapeutic payloads, but sample populations can contain distinct subpopulations. Development and quality work need quantitative insight.
Highspin applies the physics of sedimentation velocity analytical ultracentrifugation (AUC) in a streamlined platform designed to enable rich biophysical measurements of complex nanoparticles.
AAV
Empty/partial/full assessment of viral vector populations.
LNP
Lipid nanoparticle size, mass, and cargo distributions.
tLNP
Targeted lipid nanoparticle characterization.
What you can measure
Multiple answers from one analysis.
Characterize distributions and subpopulations, with measurements that connect physical properties to sample composition.
01 / POPULATION
Size distribution
Resolve how particle size varies across a sample.
02 / COMPOSITION
Mass & density
Quantify physical properties of nanoparticles in heterogeneous samples.
03 / CARGO
Payload distribution
Assess empty/partial/full fractions and cargo-related subpopulations, including mRNA copy number where applicable.
How it works
Built on proven centrifugal sedimentation analysis.
As particles sediment, differences in size, mass, shape, and density influence their behavior. Highspin merges microfluidics, high-speed confocal fluorescence detection, and custom analysis tools in an approachable workflow.
01
Load the sample
Up to 12 samples with small sample volumes (< 10 μL) and brief preparation (in minutes).
02
Measure sedimentation
Acquire signals across particle populations, with a typical run time of 30 to 120 minutes.
03
Analyze distributions
Use advanced analysis to turn traces into quantitative insight.
Collaborate
Explore your samples with Highspin.
The early technology access program provides a way to evaluate nanoparticle samples, compare findings with orthogonal methods, and explore sample testing services.
Contact us: info@highspinbio.com
01
Demonstrate the technology on your samples
02
Validate results with orthogonal methods
03
Discuss testing needs and applications
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